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J Am Acad Dermatol. 2011 Aug;65(2):304-312. doi: 10.1016/j.jaad.2010.05.042. Epub 2011 May 6.

Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer: a population-based case-control study.

Author information

1
Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
2
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island; Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island.
3
Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire.
4
Novartis Farmaceutica SA, Barcelona, Spain.
5
Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire.
6
Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
7
Division of Epidemiology and Community Health, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
8
Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire. Electronic address: Margaret.Karagas@Dartmouth.edu.

Abstract

BACKGROUND:

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially chemopreventive.

OBJECTIVE:

We examined the relation between NSAID use and nonmelanoma skin cancer in a population-based case-control study.

METHODS:

NSAID and analgesic use was analyzed in 1484 participants: 535 with squamous cell carcinoma (SCC), 487 with basal cell carcinoma (BCC), and 462 control subjects.

RESULTS:

Use of NSAIDs, particularly aspirin, was associated with a reduced odds ratio (OR) of SCC, especially tumors positive for p53 (OR 0.29; 95% confidence interval 0.11-0.79) or with PTCH loss of heterozygosity (OR 0.35; 95% confidence interval 0.13-0.96). Although not considered a NSAID, decreased ORs of both basal cell carcinoma and SCC were observed in relation to use of paracetamol (acetaminophen). Risk of BCC was unrelated to NSAID use.

LIMITATIONS:

Self-reported drug use was a limitation.

CONCLUSIONS:

This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC.

PMID:
21529996
PMCID:
PMC3140678
DOI:
10.1016/j.jaad.2010.05.042
[Indexed for MEDLINE]
Free PMC Article

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