Format

Send to

Choose Destination
Cell Calcium. 2011 Aug;50(2):157-67. doi: 10.1016/j.ceca.2011.03.011. Epub 2011 May 6.

The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.

Author information

1
Department of Cell and Developmental Biology, University College London, London, UK. patel.s@ucl.ac.uk

Abstract

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

PMID:
21529939
PMCID:
PMC3160778
DOI:
10.1016/j.ceca.2011.03.011
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center