Abstract
A 5.2-kilobase mouse RNA is expressed in human cells following infection with recombinant retroviruses propagated in mouse NIH 3T3 cells as psi-2 pseudotypes. This RNA is transcribed from a defective mink cell focus-forming provirus and copackaged into virions and integrated into human target cell DNA at a frequency comparable to that of the recombinant retrovirus genome.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Blotting, Southern
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Cell Line
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Cell Transformation, Neoplastic*
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Cells, Cultured
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Genetic Vectors*
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Humans
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Leukemia Virus, Murine / genetics*
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Mice
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Mink Cell Focus-Inducing Viruses / genetics*
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Moloney murine sarcoma virus / genetics*
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Nucleic Acid Hybridization
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Oligonucleotide Probes
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Proviruses / genetics*
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Recombination, Genetic
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Sarcoma Viruses, Murine / genetics*
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Transcription, Genetic
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Virion / genetics