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J Virol. 1990 Jan;64(1):424-7.

Human cells infected with retrovirus vectors acquire an endogenous murine provirus.

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1
Howard Hughes Medical Institute, Boston, Massachusetts.

Abstract

A 5.2-kilobase mouse RNA is expressed in human cells following infection with recombinant retroviruses propagated in mouse NIH 3T3 cells as psi-2 pseudotypes. This RNA is transcribed from a defective mink cell focus-forming provirus and copackaged into virions and integrated into human target cell DNA at a frequency comparable to that of the recombinant retrovirus genome.

PMID:
2152828
PMCID:
PMC249120
[Indexed for MEDLINE]
Free PMC Article
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