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EMBO J. 2011 May 18;30(10):1885-95. doi: 10.1038/emboj.2011.135. Epub 2011 Apr 28.

Chromatin: constructing the big picture.

Author information

1
Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, The Netherlands. b.v.steensel@nki.nl

Abstract

Chromatin is the ensemble of genomic DNA and a large number of proteins. Various genome-wide mapping techniques have begun to reveal that, despite the tremendous complexity, chromatin organization is governed by simple principles. This review discusses the principles that drive the spatial architecture of chromatin, as well as genome-wide-binding patterns of chromatin proteins.

PMID:
21527910
PMCID:
PMC3098493
DOI:
10.1038/emboj.2011.135
[Indexed for MEDLINE]
Free PMC Article

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