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Physiol Rev. 2011 Apr;91(2):389-411. doi: 10.1152/physrev.00007.2010.

Leptin and the central nervous system control of glucose metabolism.

Author information

1
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98195, USA. gjmorton@u.washington.edu

Abstract

The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.

PMID:
21527729
PMCID:
PMC3379883
DOI:
10.1152/physrev.00007.2010
[Indexed for MEDLINE]
Free PMC Article

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