Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2011 Apr 29;332(6029):586-9. doi: 10.1126/science.1201647.

Self-organizing and stochastic behaviors during the regeneration of hair stem cells.

Author information

1
Department of Pathology, University of Southern California (USC), Los Angeles, CA 90033, USA.

Abstract

Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs.

PMID:
21527712
PMCID:
PMC3321266
DOI:
10.1126/science.1201647
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center