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Chest. 2011 Nov;140(5):1325-1331. doi: 10.1378/chest.10-3280. Epub 2011 Apr 28.

Ethnic differences in fraction of exhaled nitric oxide and lung function in healthy young children.

Author information

1
Portex Unit: Respiratory Medicine and Physiology, University College London Institute of Child Health; Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children NHS Trust. Electronic address: s.sonnappa@ich.ucl.ac.uk.
2
Portex Unit: Respiratory Medicine and Physiology, University College London Institute of Child Health.
3
Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children NHS Trust.
4
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital and Imperial College, Sydney Street, London, England.
5
Portex Unit: Respiratory Medicine and Physiology, University College London Institute of Child Health; Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children NHS Trust.

Abstract

BACKGROUND:

Ethnic differences in lung function in school-aged children and adults are well recognized, but little is known about such differences in preschool children. We investigated whether differences exist in fraction of exhaled nitric oxide (Feno), multiple-breath washout (MBW) indices, specific airways resistance (sRaw), and spirometry indices between healthy preschool children of South Asian and white European origin.

METHODS:

Feno, MBW indices (lung clearance index, functional residual capacity, conductive airways inhomogeneity, and acinar airways inhomogeneity), sRaw, and spirometry were measured in healthy South Asian and white children aged 4 to 6 years, and comparisons were made between the two groups. Statistical analyses were by multiple linear regression and t tests.

RESULTS:

Thirty-seven white (mean age 5.8 ± 0.7 years, 49% boys) and 31 South Asian children (mean age 5.4 ± 0.8 years, 52% boys) were recruited. Feno was, on average, 36% higher (P < .05) in South Asian children compared with white children. FVC and FEV(1) and fractions thereof (FEV(0.75) and FEV(0.5)) z-scores were significantly lower in South Asian compared with white children by 0.69 (P = .01), 0.76 (P = .004), 0.76 (P = .009), and 0.85 (P = .002) z-scores, respectively, but there were no significant differences in FEV(1)/FVC, FEF(25-75), sRaw, or MBW indices.

CONCLUSIONS:

Differences in Feno and forced expiratory lung volumes between South Asian and white children exist from a very young age. Ethnic differences should be taken into account when interpreting lung function results in preschool children for effective management of respiratory conditions.

PMID:
21527509
DOI:
10.1378/chest.10-3280
[Indexed for MEDLINE]

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