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Nanoscale. 2011 Jun;3(6):2481-4. doi: 10.1039/c1nr10181a. Epub 2011 Apr 28.

In situ monitoring of single molecule binding reactions with time-lapse atomic force microscopy on functionalized DNA origami.

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  • 1Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.

Abstract

Individual biomolecular binding events were recorded in situ by combining time-lapse atomic force microscopy and DNA origami. Single streptavidin molecules bound to specifically biotinyated DNA origami were simply counted as a function of time to obtain a direct measure of the binding rate.

PMID:
21526259
DOI:
10.1039/c1nr10181a
[PubMed - indexed for MEDLINE]
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