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Bioorg Med Chem. 2011 May 15;19(10):3135-40. doi: 10.1016/j.bmc.2011.04.007. Epub 2011 Apr 7.

Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation.

Author information

1
Aristotle University, School of Pharmacy, Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki, Greece.

Abstract

As part of ongoing studies in developing new antimicrobials, we report the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties. Evaluation of antibacterial activity showed that almost all the compounds exhibited greater activity than reference drugs and thus could be promising novel drug candidates.

PMID:
21524583
DOI:
10.1016/j.bmc.2011.04.007
[Indexed for MEDLINE]

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