Format

Send to

Choose Destination
Epigenetics. 2011 May;6(5):566-72. Epub 2011 May 1.

Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta.

Author information

1
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.

Abstract

Birthweight has been associated with a number of health outcomes throughout life. Crucial to proper infant growth and development is the placenta, and alterations to placental gene function may reflect differences in the intrauterine environment which functionally contribute to infant growth and may ultimately affect the child's health. To examine if epigenetic alteration to the glucocorticoid receptor (GR) gene was linked to infant growth, we analyzed 480 human placentas for differential methylation of the GR gene exon 1F and examined how this variation in methylation extent was associated with fetal growth. Multivariable linear regression revealed a significant association (p < 0.0001) between differential methylation of the GR gene and large for gestational age (LGA) status. Our work is one of the first to link infant growth as a measure of the intrauterine environment and epigenetic alterations to the GR and suggests that DNA methylation may be a critical determinant of placental function.

PMID:
21521940
PMCID:
PMC3121971
DOI:
10.4161/epi.6.5.15236
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center