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Pediatr Transplant. 2011 Aug;15(5):533-8. doi: 10.1111/j.1399-3046.2011.01507.x. Epub 2011 Apr 26.

Outcome of renal transplantation in children: a multi-center national report from Iran.

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  • 1Urology and Nephrology Research Center, Shaheed Beheshti University of Medical Science, Labbafi Nejad Hospital, Ali Asghar Children's Hospital, Tehran, Iran. hasanotukesh@yahoo.com

Abstract

The outcome of pediatric renal transplantation was previously reported by a single-center study at the year 2006. Therefore, we aimed to evaluate and report the characteristics and outcome of renal pediatric renal transplantation in a multi-center nationwide study. In this nationwide report, medical records of 907 children (≤18yr) with renal transplantation in eight major pediatric transplant centers of Iran were recorded. These 907 patients received a total of 922 transplants. All children who failed to follow-up were excluded. Rather than baseline characteristics, graft and patient outcomes were considered for survival analysis. For further analysis, they were divided into two groups: patients who had graft survival time more than 10yr (n=91) and the ones with graft survival time of equal or less than 10yr (n=831). Of 922 recipients, 515 (55.8%) were boys and 407 (44.2%) were girls with the mean age of 13.10 (s.d.=3.54) yr. DGF and AR were occurred in 10% and 39.5% of the transplanted children, respectively. Transplantation year, dialyzing status before transplantation, DGF, and AR were significant enough to predict graft survival in cox regression model (overall model: p<0.001). Nowadays, there is a successful live donor pediatric renal transplantation in Iran. Graft survival has improved in our recipients and now the graft survival rates are near to international standards.

[PubMed - indexed for MEDLINE]
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