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Psychiatry Investig. 2011 Mar;8(1):22-9. doi: 10.4306/pi.2011.8.1.22. Epub 2010 Nov 27.

Factors affecting treatment discontinuation and treatment outcome in patients with schizophrenia in Korea: 10-year follow-up study.

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1
Department of Psychiatry, In-ha University College of Medicine, Incheon, Korea.

Abstract

OBJECTIVE:

There have been few long-term studies that have assessed factors influencing treatment discontinuation and long-term outcome of schizophrenia in Korea. The present study aimed to evaluate factors affecting treatment discontinuation and treatment outcome, after 10 years, in patients with schizophrenia.

METHODS:

Among hospitalized patients between 1997 and 1999, 191 patients were given continuous follow-up service. We examined the clinical characteristics and outcome of patients who remained in treatment. Regression analyses were used to find any clinical factors affecting treatment discontinuation.

RESULTS:

One hundred thirty-three patients (71.12%) discontinued the treatment. The treatment retention group contained more female patients, paranoid-type patients, patients who had shown self-harming behavior, patients receiving clozapine, and patients with good medication compliance. The recovery rate was 25%. However, 42.3% did not have gainful employment. Further, most patients couldn't live independently.

CONCLUSION:

The results show the importance of gender, patient behavior, medication, and medication compliance in predicting treatment discontinuation in patients with schizophrenia.

KEYWORDS:

Discontinuation; Follow-up; Long-term; Outcome; Schizophrenia; Treatment

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