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EuroIntervention. 2011 Apr;6(9):1068-72. doi: 10.4244/EIJV6I9A186.

Gender-related differences in mortality after ST-segment elevation myocardial infarction: a large multicentre national registry.

Author information

1
Swietokrzyskie Centrum Kardiologii, Kielce, Poland. emsad@o2.pl

Abstract

AIMS:

Clinical outcomes in the treatment of acute ST-segment elevation myocardial infarction (STEMI) differ between men and women. The aim of the study was to compare results of STEMI management in a large multicentre national registry.

METHODS AND RESULTS:

A total of 456 hospitals (including 58 interventional centres) participated in the registry during one year. The study group consisted of 8,989 (34.5%) females and 17,046 (65.5%) males. Women were older (69.7 ± 11 vs. 62 ± 12 years; p<0.0001) and had more risk factors. Percutaneous coronary intervention was performed significantly less in women (47.8% vs. 57.4%; p<0.0001). There was a longer time delay in women at each stage of treatment. The incidence of in-hospital complications was higher in women. In-hospital (11.9% vs. 6.9%; p<0.0001) and 12-months (22% vs. 14.1%; p<0.0001) mortality was significantly higher in women. In multivariate analysis pulmonary oedema, cardiogenic shock, cardiac arrest, age, diabetes and anterior infarction significantly increased both in-hospital and long-term mortality. The in-hospital mortality was higher in the female group.

CONCLUSIONS:

Despite poor clinical characteristics, less than satisfactory management and a worse prognosis of STEMI in women, being a women itself is not a risk factor for increased long-term mortality, however, other well known risk factors affecting the prognosis relate frequently to the female gender.

PMID:
21518678
DOI:
10.4244/EIJV6I9A186
[Indexed for MEDLINE]

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