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J Dtsch Dermatol Ges. 2011 Sep;9(9):670-6. doi: 10.1111/j.1610-0387.2011.07656.x. Epub 2011 Apr 26.

Genetics of atopic dermatitis.

[Article in English, German]

Author information

1
Department of Dermatology and Allergy, University of Bonn, Germany.

Abstract

Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.

[Indexed for MEDLINE]

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