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Br J Clin Pharmacol. 2011 Oct;72(4):647-57. doi: 10.1111/j.1365-2125.2011.03999.x.

Anti-platelet therapy: ADP receptor antagonists.

Author information

1
Division of Cardiovascular Medicine, School of Clinical Sciences, University of Nottingham, Nottingham, UK. ydw@doctors.org.uk

Abstract

The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.

PMID:
21518389
PMCID:
PMC3187865
DOI:
10.1111/j.1365-2125.2011.03999.x
[Indexed for MEDLINE]
Free PMC Article

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