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J Pediatr Hematol Oncol. 2011 May;33(4):e163-5. doi: 10.1097/MPH.0b013e3182122422.

Acute nonimmune hemolytic anemia without fulminant hepatitis in Wilson disease.

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Children's Hospital and Research Center Oakland, Oakland, CA 94609, USA.


Owing to the insidious course and variable presentation, Wilson disease is often diagnosed months to years after the initial symptoms. Although fulminant hepatitis with nonimmune hemolytic anemia is frequently reported, chronic mild hepatitis can occur with bouts of transient hemolytic anemia. We report a 16-year-old female who presented with fatigue, dizziness, and new onset jaundice. She had a hemolytic anemia, although diagnosis of Wilson disease was initially confounded by a family history of autoimmunity with a high erythrocyte sedimentation rate and only mildly elevated bilirubin and aspartate aminotransferase. Macrocytosis, poor liver synthetic function, and low serum alkaline phosphatase led to the diagnosis.

[Indexed for MEDLINE]

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