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Diabetes Care. 2011 Jun;34(6):1400-2. doi: 10.2337/dc11-0103. Epub 2011 Apr 22.

Vitamin D deficiency is associated with retinopathy in children and adolescents with type 1 diabetes.

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  • 1School of Women's and Children's Health, University of New South Wales, New South Wales, Australia.

Abstract

OBJECTIVE:

To examine the hypothesis that vitamin D deficiency (VDD) is associated with an increased prevalence of microvascular complications in young people with type 1 diabetes.

RESEARCH DESIGN AND METHODS:

In a cross-sectional study of 517 patients, 25-hydroxyvitamin D was measured. Retinopathy was assessed by 7-field stereoscopic retinal photography, peripheral neuropathy by thermal and vibration threshold testing, and microalbuminuria by albumin excretion rate or albumin-to-creatinine ratio.

RESULTS:

Retinopathy prevalence was higher in cases with VDD versus sufficiency (18 vs. 9%, P = 0.02); deficiency was not associated with microalbuminuria or neuropathy. In logistic regression, retinopathy was associated with VDD (odds ratio 2.12 [95% CI 1.03-4.33]), diabetes duration (1.13, 1.05-1.23), and HbA(1c) (1.24, 1.02-1.50).

CONCLUSIONS:

VDD is associated with an increased prevalence of retinopathy in young people with type 1 diabetes. The inflammatory and angiogenic effects of VDD may contribute to early retinal vascular damage; however, further investigations are warranted.

PMID:
21515836
PMCID:
PMC3114351
DOI:
10.2337/dc11-0103
[PubMed - indexed for MEDLINE]
Free PMC Article
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