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Cell Signal. 2011 Aug;23(8):1273-80. doi: 10.1016/j.cellsig.2011.04.005. Epub 2011 Apr 15.

Emerging roles of DNA-PK besides DNA repair.

Author information

1
Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

The DNA-dependent protein kinase (DNA-PK) is a DNA-activated serine/threonine protein kinase, and abundantly expressed in almost all mammalian cells. The roles of DNA-PK in DNA-damage repair pathways, including non-homologous end-joining (NHEJ) repair and homologous recombinant (HR) repair, have been studied intensively. However, the high levels of DNA-PK in human cells are somewhat paradoxical in that it does not impart any increased ability to repair DNA damage. If DNA-PK essentially exceeds the demand for DNA damage repair, why do human cells universally express such high levels of this huge complex? DNA-PK has been recently reported to be involved in metabolic gene regulation in response to feeding/insulin stimulation; our studies have also suggested a role of DNA-PK in the regulation of the homeostasis of cell proliferation. These novel findings expand our horizons about the importance of DNA-PK.

PMID:
21514376
DOI:
10.1016/j.cellsig.2011.04.005
[Indexed for MEDLINE]

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