Format

Send to

Choose Destination
Trends Endocrinol Metab. 2011 Jul;22(7):286-93. doi: 10.1016/j.tem.2011.02.009. Epub 2011 Apr 21.

Molecular basis of the obesity associated with Bardet-Biedl syndrome.

Author information

1
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Abstract

Bardet-Biedl Syndrome (BBS) is a rare human hereditary disorder associated with several features including obesity, retinopathy, renal defects, polydactyly, learning disabilities and hypogenitalism. This article discusses the abnormalities accounting for energy imbalance leading to obesity in BBS, with emphasis on the recent evidence pointing to aberrations in hypothalamic action of leptin. Indeed, BBS proteins have emerged as important mediators of leptin receptor trafficking, and loss of BBS genes results in leptin resistance that could be due to abnormal leptin receptor handling in a subset of leptin-responsive neurons. These recent discoveries hold promise for improved clinical management of BBS patients. The relevance of these findings to non-syndromic common obesity is also discussed.

PMID:
21514177
PMCID:
PMC3130119
DOI:
10.1016/j.tem.2011.02.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center