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Curr Opin Struct Biol. 2011 Jun;21(3):306-18. doi: 10.1016/j.sbi.2011.03.015. Epub 2011 Apr 21.

Computational approaches to RNA structure prediction, analysis, and design.

Author information

1
Department of Chemistry, Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA.

Abstract

RNA molecules are important cellular components involved in many fundamental biological processes. Understanding the mechanisms behind their functions requires RNA tertiary structure knowledge. Although modeling approaches for the study of RNA structures and dynamics lag behind efforts in protein folding, much progress has been achieved in the past two years. Here, we review recent advances in RNA folding algorithms, RNA tertiary motif discovery, applications of graph theory approaches to RNA structure and function, and in silico generation of RNA sequence pools for aptamer design. Advances within each area can be combined to impact many problems in RNA structure and function.

PMID:
21514143
PMCID:
PMC3112238
DOI:
10.1016/j.sbi.2011.03.015
[Indexed for MEDLINE]
Free PMC Article

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