Format

Send to

Choose Destination
Diabetes Res Clin Pract. 2011 Jul;93(1):43-8. doi: 10.1016/j.diabres.2011.03.028. Epub 2011 Apr 21.

Hepcidin expression and iron parameters change in Type 2 diabetic patients.

Author information

1
Department of Hematology Laboratory, The First Affiliated Hospital Of Shantou University Medical College, 57 Changping Road, Shantou, Guangdong 515041, China.

Abstract

AIM:

Iron may contribute to the pathogenesis of Type 2 diabetes mellitus (DM). The aim of this study was to determine iron regulator hepcidin and iron metabolic parameters in Type 2 DM patients, the relationships among them were evaluated in this specific sub-groups.

MATERIALS AND METHODS:

The study included sixty-four people: 34 cases of diabetes and 30 age-matched controls. Serum hepcidin, IL-6, hsCRP, ferritin, sTfR, EPO as well as other clinical parameters were detected, and the associations between hepcidin levels and iron/inflammatory parameters were analyzed in diabetes and the controls.

RESULTS:

Serum ferritin and hepcidin levels in diabetic patients were significant higher than the controls (p<0.001 respectively). A positive correlation between hepcidin and ferritin, as well as between ferritin and IL-6 levels was existed in diabetes and the control groups (p<0.001 respectively).

CONCLUSION:

All of these data demonstrated that the higher hepcidin levels in diabetic patients may be due to those higher ferritin and IL-6 levels, the elevated hepcidin might have adaptive value through down-regulated iron absorb and play an important role in pathogenesis of Type 2 DM.

PMID:
21513996
DOI:
10.1016/j.diabres.2011.03.028
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center