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Chem Biol. 2011 Apr 22;18(4):405-7. doi: 10.1016/j.chembiol.2011.04.004.

Drug resistance: a periplasmic ménage à trois.

Author information

1
Institute of Biochemistry and Cluster of Excellence Frankfurt-Macromolecular Complexes, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.

Abstract

The paradigm tripartite efflux transporter AcrA-AcrB-TolC confers multiple drug resistance to Escherichia coli. Tikhonova et al. (2011) now examine how the three components connect to unity and highlight the critical role of AcrA membrane proximal domain conformation for successful assembly.

PMID:
21513873
DOI:
10.1016/j.chembiol.2011.04.004
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