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Org Lett. 2011 May 20;13(10):2548-51. doi: 10.1021/ol200628n. Epub 2011 Apr 22.

Palladium-catalyzed C-H perfluoroalkylation of arenes.

Author information

1
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Abstract

A new Pd-catalyzed reaction for the coupling between perfluoroalkyl iodides (R(F)I) and simple aromatic substrates is described. The perfluoroalkylated arene products are obtained in good to excellent yields in the presence of a phosphine-ligated Pd catalyst and Cs(2)CO(3) as a base. The development, optimization, scope, and preliminary mechanistic studies of these transformations are reported.

PMID:
21513298
DOI:
10.1021/ol200628n
[Indexed for MEDLINE]

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