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Immunity. 2011 Apr 22;34(4):466-78. doi: 10.1016/j.immuni.2011.04.008.

Cell surface signaling molecules in the control of immune responses: a tide model.

Author information

1
Department of Immunobiology and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06519, USA.

Abstract

A large numbers of cell surface signaling molecules (CSSMs) have been molecularly identified and functionally characterized in recent years and, via these studies, our knowledge in the control of immune response has increased exponentially. Two major lines of evidence emerge. First, the majority of immune cells rely on one or few CSSMs to deliver a primary triggering signal to sense their environment, leading to initiation of an immune response. Second, both costimulatory CSSMs that promote the response, and coinhibitory CSSMs that inhibit the response, are required to control direction and magnitude of a given immune response. With such tight feedback, immune responses are tuned and returned to baseline. These findings extend well beyond our previous observation in the requirement for lymphocyte activation and argue a revisit of the traditional "two-signal model" for activation and tolerance of lymphocytes. Here we propose a "tide" model to accommodate and interpret current experimental findings.

PMID:
21511182
PMCID:
PMC3176719
DOI:
10.1016/j.immuni.2011.04.008
[Indexed for MEDLINE]
Free PMC Article

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