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Immunity. 2011 Apr 22;34(4):453-5. doi: 10.1016/j.immuni.2011.04.001.

Special delivery: granulin brings CpG DNA to Toll-like receptor 9.

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Department of Genetics, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.


Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et al. (2011) present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.

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