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Acta Trop. 2011 Jul;119(1):1-4. doi: 10.1016/j.actatropica.2011.04.002. Epub 2011 Apr 9.

Trypanosoma cruzi I diversity: towards the need of genetic subdivision?

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1
Centro de Investigaciones en Microbiología y Parasitología Tropical, CIMPAT, Universidad de los Andes, Cra 1 No. 18A-10, Bogotá, Colombia. fguhl@uniandes.edu.co

Abstract

Trypanosoma cruzi the aethiological agent of Chagas disease, a complex zoonoses that affects the American continent is a genetically variable parasite subdivided into six Discrete Typing Units (DTUs). T. cruzi I is the most prevalent DTU affecting the northern countries of America with sporadical cases in the southern countries. T. cruzi I has shown great genetic diversity showing plausible subdivisions needed for this group. Recently, TcI has gained novel importance because of the lately discovered relation with cardiomyopathy manifestations that raises the importance of establishing subdivisions within this DTU.

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