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Nat Rev Mol Cell Biol. 2011 May;12(5):308-19. doi: 10.1038/nrm3112.

Balancing forces: architectural control of mechanotransduction.

Author information

1
Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco (UCSF), CA, USA.

Abstract

All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations to mechanotransduction, from the nanoscale-level to the tissue-level, which compromises tensional homeostasis to promote pathologies such as cardiovascular disease and cancer. The mechanisms of such perturbations suggest that a complex interplay exists between the extracellular microenvironment and cellular function. Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.

PMID:
21508987
PMCID:
PMC3564968
DOI:
10.1038/nrm3112
[Indexed for MEDLINE]
Free PMC Article

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