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Clin Obstet Gynecol. 2011 Jun;54(2):358-69. doi: 10.1097/GRF.0b013e318217ee18.

Impact of preterm PROM and its complications on long-term infant outcomes.

Author information

1
Department of Obstetrics and Gynecology at University of Utah, Salt Lake City, Utah, USA. erin.clark@hsc.utah.edu

Abstract

There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.

PMID:
21508707
DOI:
10.1097/GRF.0b013e318217ee18
[Indexed for MEDLINE]

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