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Neuroepidemiology. 2011;36(3):155-61. doi: 10.1159/000325653. Epub 2011 Apr 20.

Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease.

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1
Department of Epidemiology, School of Public Health, UCLA, Los Angeles, CA 90095–1772, USA.

Abstract

BACKGROUND:

Experimental evidence supports a preventative role for non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease (PD).

METHODS:

We investigated associations between use of aspirin, nonaspirin NSAIDs, and acetaminophen and PD in a large population-based case-control study using Danish health and pharmacy registries. We identified 1,931 PD cases reported in hospital or outpatient clinic records who had received a primary diagnosis of PD between 2001 and 2006, and 9,651 age- and sex-matched controls from the Danish population register. Prescription medication use was documented in a pharmacy database covering all residents of Denmark since 1995.

RESULTS:

Adjusting for age, sex, use of cardiovascular disease drugs, diagnosis of chronic pulmonary obstructive disorder, and Charlson comorbidity scores, and excluding prescriptions filled within 5 years before diagnosis, we found no evidence for an association between PD and either aspirin use (OR = 0.97; 95% CI 0.82, 1.14) or nonaspirin NSAID use (OR = 0.97; 95% CI 0.86, 1.09), regardless of intensity of use; further, there was no association between use of ibuprofen or acetaminophen and PD.

CONCLUSION:

Our findings provide no evidence for a protective effect of nonaspirin and aspirin NSAID prescription drug use shortly before PD onset.

PMID:
21508649
PMCID:
PMC3095838
DOI:
10.1159/000325653
[Indexed for MEDLINE]
Free PMC Article
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