In this paper we discuss the problems of particle advection, manipulation and mixing at small scales. We start by considering reaction-advection-diffusion systems with the focus on mixing. We show how mixing advection affects the processes of reaction-diffusion and discuss mixing-induced instabilities. Further, we consider the problem of particle manipulation and discuss collective effects in systems comprising solid and compressible particles. We particularly discuss mechanisms of particle entrapment, the role of compressibility in the dynamics of bubbly liquids and nonequilibrium colloidal explosion. Finally, we address two issues related to the problem of wetting. First, we study the role of contact line motion for a sessile droplet (or a bubble) on an oscillating substrate. Second, we discuss an instability of a thin film leading to the formation of a fractal structure of droplets.