Development and integration of image registration methods become increasingly important for clinical workstations. Due to the complexity of such methods, prototyping, evaluation and workflow integration require in-depth knowledge foremostly available to registration developers. Rapid development and deployment is therefore often difficult, particularly for comprehensive software frameworks. In this article, we introduce a novel rapid prototyping framework for voxel-based registration. It is specifically designed to allow evaluation and adaption by developers with less knowledge on registration internals. Based on a unique "one-iteration" paradigm, it enables accelerated algorithm development. Furthermore, methods are interchangeable at runtime using an intuitive graphical plugin interface, allowing a genuine comparison of methods. We discuss the concepts of this framework, compare it to other software and demonstrate its effectiveness for several demanding registration applications, highlighting its versatility and reliability.
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