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Prog Mol Biol Transl Sci. 2011;101:193-218. doi: 10.1016/B978-0-12-387685-0.00005-6.

DNA methylation in zebrafish.

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Developmental Biology Program, Sloan-Kettering Institute, New York, USA.


DNA methylation is crucial for normal development and cellular differentiation in many large-genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently emerged as a powerful system for the study of DNA methylation, especially in the context of development. This review summarizes our current knowledge of DNA methylation in zebrafish and provides evidence for the general conservation of this system with mammals. In addition, emerging strategies are highlighted that use the fish model to address some of the key unanswered questions in DNA methylation research.

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