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J Parasitol. 2011 Aug;97(4):620-8. doi: 10.1645/GE-2712.1. Epub 2011 Feb 11.

A review: Competence, compromise, and concomitance-reaction of the host cell to Toxoplasma gondii infection and development.

Author information

1
Department of Etio-biology, School of Public Health and Tropical Medicine, Southern Medical University, 1838 North Guangzhou Rd, Guangzhou, Guangdong Province 510515, People's Republic of China.

Abstract

Toxoplasma gondii is an important zoonotic parasite with a worldwide distribution. It infects about one-third of the world's population, causing serious illness in immunosuppressed individuals, fetuses, and infants. Toxoplasma gondii biology within the host cell includes several important phases: (1) active invasion and establishment of a nonfusogenic parasitophorous vacuole in the host cell, (2) extensive modification of the parasitophorous vacuolar membrane for nutrient acquisition, (3) intracellular proliferation by endodyogeny, (4) egress and invasion of new host cells, and (5) stage conversion from tachyzoite to bradyzoite and establishment of chronic infection. During these processes, T. gondii regulates the host cell by modulating morphological, physiological, immunological, genetic, and cellular biological aspects of the host cell. Overall, the infection/development predispositions of T. gondii -host cell interactions overtakes the infection resistance aspects. Upon invasion and development, host cells are modulated to keep a delicate balance between facilitating and eliminating the infection.

PMID:
21506833
DOI:
10.1645/GE-2712.1
[Indexed for MEDLINE]

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