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Mov Disord. 2011 Mar;26(4):750-3. doi: 10.1002/mds.23504. Epub 2011 Feb 1.

Long-term follow-up of botulinum toxin therapy for focal hand dystonia: outcome at 10 years or more.

Author information

1
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Abstract

BACKGROUND:

Previous studies have explored the efficacy and safety of botulinum neurotoxin (BoNT) treatment for Focal hand dystonia (FHD), but none have followed a large number of patients for 10 years or more.

METHODS:

Retrospective study, with benefit and weakness assessed on a 0 to 4 subjective scale. Demographic, clinical and treatment characteristics were analyzed using t tests and Pearson correlations.

RESULTS:

Twenty FHD patients had 10 years or longer treatment. Interinjection intervals were variable. Musicians were more likely to wait longer between injections and had less complex dystonia. There was a trend for larger benefit in women and with shorter intervals. The dose increased over time. Dystonia characteristics did not predict response or side-effects, but benefit magnitude predicted longer compliance. No serious side-effects or antibody-mediated resistance occurred.

CONCLUSION:

This is the longest reported period of BoNT treatment in the largest FHD cohort. BoNT therapy for FHD remains safe and effective after more than a decade of treatment.

PMID:
21506157
PMCID:
PMC3081109
DOI:
10.1002/mds.23504
[Indexed for MEDLINE]
Free PMC Article

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