Format

Send to

Choose Destination
Org Biomol Chem. 2011 Jun 7;9(11):4044-50. doi: 10.1039/c1ob05238a. Epub 2011 Apr 19.

Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water.

Author information

1
Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan. hidemasa.hikawa@phar.toho-u.ac.jp

Abstract

Palladium-catalyzed N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol were carried out. The reaction in the presence of Pd(OAc)(2) (5 mol%), sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol%), and AcONa (2 equiv) in water at 120 °C for 16 h in a sealed tube gave only mono-N-allylated amino acids in good yield.

PMID:
21505697
DOI:
10.1039/c1ob05238a
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center