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Nat Rev Neurosci. 2011 May;12(5):251-68. doi: 10.1038/nrn3009.

The role of ubiquitylation in nerve cell development.

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Max Planck Institute of Experimental Medicine, Department of Molecular Neurobiology, Hermann-Rein Straße 3, D-37075 Göttingen, Germany. kawabe@em.mpg. de


Nerve cell development in the brain is a tightly regulated process. The generation of neurons from precursor cells, their migration to the appropriate target sites, their extensive arborization and their integration into functional networks through synapse formation and refinement are governed by multiple interdependent signalling cascades. The function and turnover of proteins involved in these signalling cascades, in turn, are spatially and temporally controlled by ubiquitylation. Recent advances have provided first insights into the highly complex and intricate molecular pathways that regulate ubiquitylation during all stages of neural development and that operate in parallel with other regulatory processes such as phosphorylation or cyclic nucleotide signalling.

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