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Hautarzt. 2011 May;62(5):375-9. doi: 10.1007/s00105-011-2148-3.

[Treatment of crow's feet with two different botulinum toxin type A preparations in split-face technique].

[Article in German]

Author information

1
Dermatologikum Hamburg, Stephansplatz 5, Hamburg, Germany. prager@dermatologikum.de

Abstract

BACKGROUND:

For the first time, the effectiveness of Xeomin®, and Dysport® in an dose-ratio of 1:3 treating crow's feet (FWS 2-3) was evaluated in a double-blind randomized pilot study.

PATIENTS AND METHOD:

Xeomin® (12 units) was compared to Dysport® (36 units) in an intra-individual split-face technique in 22 patients over a period of 4 months. According to the facial-wrinkle-scale (FWS) patients were rated as responders with an improvement of at least 1 point in FWS.

RESULTS:

One month after treatment significantly more than 80% of patients were rated as responders. The different products proved to be equivalent in response rate and effectiveness with no significant difference after 4 weeks and 4 months in statistical analysis. Surprisingly the decrease in FWS of crows' feet at rest was more pronounced.

CONCLUSION:

The different botulinum toxin type A formulations proved to be equivalent in effectiveness and tolerability in a dose ratio of 1:3 (Xeomin®: Dysport®) The more pronounced decrease of crow's feet at rest points out the importance of muscle insertion into the skin for the cosmetic result in the periorbital region.

PMID:
21503782
DOI:
10.1007/s00105-011-2148-3
[Indexed for MEDLINE]

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