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Fukushima J Med Sci. 2010 Dec;56(2):115-20.

Flow-mediated dilatation identifies impaired endothelial function in patients with sleep apnea syndrome.

Author information

1
Department of Cardiology and Hematology, Fukushima Medical University, Japan. yoshihis@fmu.ac.jp

Abstract

BACKGROUND:

Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient.

METHODS:

Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36).

RESULTS:

There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01).

CONCLUSIONS:

Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS.

PMID:
21502711
DOI:
10.5387/fms.56.115
[Indexed for MEDLINE]
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