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Adv Protein Chem Struct Biol. 2011;82:91-9. doi: 10.1016/B978-0-12-386507-6.00004-X.

Correlative light-electron microscopy.

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Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.


Recent advances in combining light and electron microscopy imaging techniques provide the means to correlate dynamic biological processes with the underlying structural correlates in situ. In this chapter, we provide snapshots of current advances targeting quantitative correlation of the dynamic state of a biological pathway with high-resolution structural information in the same window of time and space.

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