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Curr Top Dev Biol. 2011;95:93-144. doi: 10.1016/B978-0-12-385065-2.00004-9.

Cortical forces in cell shape changes and tissue morphogenesis.

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IBDML, UMR6216 CNRS-Université de Méditerraneé, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France.


Cortical forces drive a variety of cell shape changes and cell movements during tissue morphogenesis. While the molecular components underlying these forces have been largely identified, how they assemble and spatially and temporally organize at cell surfaces to promote cell shape changes in developing tissues are open questions. We present here different key aspects of cortical forces: their physical nature, some rules governing their emergence, and how their deployment at cell surfaces drives important morphogenetic movements in epithelia. We review a wide range of literature combining genetic/molecular, biophysical and modeling approaches, which explore essential features of cortical force generation and transmission in tissues.

[Indexed for MEDLINE]

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