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Rev Med Chir Soc Med Nat Iasi. 2010 Oct-Dec;114(4):1012-6.

[Risk factors for Pseudomonas aeruginosa infections, resistant to carbapenem].

[Article in Romanian]

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Facultatea de Medicină, Clinica de Boli Infecţioase, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.


Since their introduction in clinical practice,carbapenems have been among the most powerful antibiotics for treating serious infections cased by Gram-negative nosocomial pathogens, including Pseudomonas aeruginosa. The emergence of betalactamases with carbapenem-hydrolyzing activity is of major clinical concern. Pseudomonas aeruginosa is a leading cause of nosocomial infection.


Risk factors for colonization with carbapenems-resistant Pseudomonas in hospital are: history of P. aeruginosa infection or colonization within the previous year, (length of hospital stay, being bedridden or in the ICU, mechanical ventilation, malignant disease, and history of chronic obstructive pulmonary disease have all been identified as independent risk factors for MDR P. aeruginosa infection. Long-term-care facilities are also reservoirs of resistant bacteria. Risk factors for colonization of LTCF residents with resistant bacteria included age > 86 years, antibiotic treatment in the previous 3 months, indwelling devices, chronic obstructive pulmonary disease, physical disability, and the particular LTCF unit.

[Indexed for MEDLINE]

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