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J Cardiovasc Pharmacol. 2011 Jul;58(1):20-4. doi: 10.1097/FJC.0b013e31821c471b.

Drug exposure in pregnancy and heart defects.

Author information

1
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, University of Toronto, Toronto, Canada.

Abstract

Being the most common group of congenital malformations, congenital heart defects have often been investigated to rule out teratogenic effects by medicinal drugs and chemicals. Yet, the use of rigorous epidemiological methods has rejected such claims in many cases. We critically evaluate drugs believed to be associated with an increased risk of causing congenital heart defects, highlighting the debate and the practical implications of such associations.

PMID:
21499119
DOI:
10.1097/FJC.0b013e31821c471b
[Indexed for MEDLINE]

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