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Curr Opin Otolaryngol Head Neck Surg. 2011 Jun;19(3):224-8. doi: 10.1097/MOO.0b013e3283465687.

Vitamin D: immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis.

Author information

1
Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.

Abstract

PURPOSE OF REVIEW:

To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS).

RECENT FINDINGS:

Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vitamin D function and innate and adaptive immunity to infections. The mechanisms underlying vitamin D immune actions could be attributed to a paracrine feedback loop that reduces inflammation as well as influencing the differentiation fate of activated CD4 T cells, or the enhancement of suppressor T-cell function; indeed, a combination of these factors may underlie the actions of vitamin D.

SUMMARY:

Recent findings on the function of vitamin D may explain aspects of the pathophysiology of allergic rhinitis and CRS and may help direct future interventions and treatment of these diseases.

PMID:
21499100
DOI:
10.1097/MOO.0b013e3283465687
[Indexed for MEDLINE]

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