Format

Send to

Choose Destination
Dev Cell. 2011 Apr 19;20(4):414-6. doi: 10.1016/j.devcel.2011.04.003.

iRhoms: ERADicating the messenger in growth control signaling.

Author information

1
Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

Abstract

iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center