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Int Immunopharmacol. 2011 Sep;11(9):1234-40. doi: 10.1016/j.intimp.2011.04.002. Epub 2011 Apr 15.

Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity.

Author information

1
Department of Immunology of Shanghai Medical College, Key Laboratory of Molecular Medicine of Ministry of Education, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People's Republic of China.

Abstract

Curcumin, a yellow pigment extracted from turmeric, is widely used to inhibit tumor progression. Since it can either promote or suppress the immune system, how curcumin affects the immune system in tumor-bearing bodies is not yet clear. Our study found that tumor-bearing mice treated consecutively once a day with low-dose curcumin for ten days led to a retarded tumor growth and a longer survival, which might be contributed to T cell-mediated adaptive immune response. The in vitro study also showed that a high-dose curcumin decreases T cells whereas a low-dose increases T cells derived from 3LL tumor-bearing mice, especially CD8+ T cells. Accordingly, these increased CD8+ T cells exhibited the enhancement of IFN-γ secretion, proliferation and cytotoxicity specifically against 3LL tumor cells, which may result in the success of antitumor immunity. Our research demonstrated a beneficial effect of curcumin on CD8+ T cells derived from tumor-bearing mice, which can provide a potential application in anti-tumor therapy.

PMID:
21497674
DOI:
10.1016/j.intimp.2011.04.002
[Indexed for MEDLINE]

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