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Diabetes Res Clin Pract. 2011 Jul;93(1):86-94. doi: 10.1016/j.diabres.2011.03.016. Epub 2011 Apr 14.

Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.

Author information

1
Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. m_farvid@sbmu.ac.ir

Abstract

AIM:

The aim of the present study was to determine if micronutrients supplementation can improve neuropathy indices in type 2 diabetes.

MATERIALS AND METHODS:

In this randomized, double-blind, placebo-controlled clinical trial, 75 type 2 diabetes patients were assigned to three treatment groups, receiving one of the following daily supplement for 4 months: Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg); Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg), biotin (200 μg), B12 (10 μg) and folic acid (1 mg); Group P: placebo.

RESULTS:

67 patients completed the study. Neuropathic symptoms based on the MNSI questionnaire improved from 3.45 to 0.64 (p=0.001) in group MVB, from 3.96 to 1.0 (p=0.001) in group MV and from 2.54 to 1.95 in placebo group after 4 months. There was no significant difference between three treatment groups in MNSI examinations after 4 months supplementations. Over 4 months of treatment, patients showed no significant changes in glycemic control, capillary blood flow or electrophysiological measures in MV and MVB groups compared with placebo group.

CONCLUSIONS:

These studies suggest that micronutrients supplementation might ameliorate diabetic neuropathy symptoms.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01173315.

PMID:
21496936
DOI:
10.1016/j.diabres.2011.03.016
[Indexed for MEDLINE]

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