Format

Send to

Choose Destination
See comment in PubMed Commons below
Drug Metabol Drug Interact. 2011;26(2):79-80. doi: 10.1515/DMDI.2011.106. Epub 2011 Apr 18.

Rhabdomyolysis-induced acute renal failure due to itraconazole and simvastatin association.

Author information

1
Intensive Care Department, Brugmann University Hospital, Brussels, Belgium.

Abstract

We present the case of an 82-year-old man admitted to our hospital for muscle weakness. He was under simvastatin 20 mg per day and was given pulse itraconazole therapy 8 days before the onset of symptoms for onychomycosis. He developed severe rhabdomyolysis inducing an acute renal failure necessitating renal replacement therapy. He eventually fully recovered. Given the possible concurrent use of simvastatin and itraconazole, awareness of this potential interaction is clinically important.

PMID:
21495875
DOI:
10.1515/DMDI.2011.106
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for iFactory
    Loading ...
    Support Center