Abstract
A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for 1 was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1-4 were evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Carboxylic Acids
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Drug Screening Assays, Antitumor
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Geologic Sediments / chemistry
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Humans
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Imidazoles / chemistry
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Imidazoles / isolation & purification*
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Imidazoles / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Penicillium / chemistry*
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Quinazolinones / chemistry
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Quinazolinones / isolation & purification*
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Quinazolinones / pharmacology
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Triazoles / chemistry
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Triazoles / isolation & purification*
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Triazoles / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents
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Carboxylic Acids
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Imidazoles
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Quinazolinones
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Triazoles
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penipanoid A
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penipanoid B
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penipanoid C