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J Mammary Gland Biol Neoplasia. 2011 Jun;16(2):97-108. doi: 10.1007/s10911-011-9217-1. Epub 2011 Apr 15.

TGF-β signaling in breast cancer cell invasion and bone metastasis.

Author information

1
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands. y.s.drabsch@lumc.nl

Abstract

The contribution of transforming growth factor β (TGF-β) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-β may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-β switches towards malignant conversion and progression. TGF-β stimulates cell invasion and modifies the microenvironment to the advantage of cancer cells. Studies have shown that TGF-β promotes bone and lung metastasis via different mechanisms. The therapeutic strategies to target the TGF-β pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-β in breast cancer invasion and metastasis.

PMID:
21494783
PMCID:
PMC3095797
DOI:
10.1007/s10911-011-9217-1
[Indexed for MEDLINE]
Free PMC Article

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